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EASTUsing EAST

The EAST tool consists of three sections, that are called consecutively. The first section is the selection of the chemical compound. The next section is for the selection of the commodity, and concentration of the chemical compound, and the exposure scenario (i.e. consumer, and region). Then the system will calculate the intake values, and report an overview of the results in the last section.

Selection of a chemical substance

The system provides two ways to select a chemical substance. The user selects how to proceed by means of two radio buttons []. The first radio button refers to a search field where a (part of a) name can be provided, to look for one or more chemicals in a database that meet yout input. E.g. input of Lead leads to a list with chemicals, including Lead (total) and Tetraethyl lead. For each a (series of) HBGV(s) is given. They are presented with radio buttons for the user to select the one to use.
For the second way, you have to provide the HBGV yourself. For this you have to provide the type of HBGV from a standard list, give the numerical value, and select the appropriate unit. A reference is optional. Beware: if you select the TWI (Tolerable Weekly Intake) or a similar type, the system will not check for the correct unit (per kg bodyweight per week in stead of per day).

Selection of a food commodity and concentration, and scenarios

Then the system asks for a food commodity. The user provides a name in a search field where a (part of a) name can be used to look for commodities that meet the input. One should also provide the concentration for the chemical compound and its unit (i.e. mg or ug or ng per kg). This concentration can be corrected for composition of the commodity and processing. The composition can be corrected by a percentage (e.g. when a concentration is reported per kg fat, then one has to correct for the amount of fat in the commodity). Correction for processing is usually done for pesticides, e.g. for canned foods on the basis of chemical analysis is raw food samples. Further more, one must select the body weight of the consumer, and an exposure scenario. For the latter you can select standardized EU scenarios, and/or provide a value for your own consumption quantity.

Commodities and scenarios

The system will look for a commodity in its database that fits your input. E.g. input of Egg leads to a list with commodities, including aubergines [egg plants], birds eggs, eggs: chicken, and some more. These commodities are presented with radio buttons. You are asked to select one commodity from that list.
At the next page the system provides you with a list of EU scenarios. These scenarios are taken from the EFSA PRIMo database, and describe the daily intake of the food commodity per kg bodyweight for the various member states and regions. Through tickboxes you are requested to select one or more scenarios.

Evaluation

The system will provide you with a summary of the results of the calculations for the scenarios you selected, and/or your own scenario. At first it will present an overview of your input; i.e. chemical compound, commodity, concentration of the chemical, and the HBGV. Besides it will show the Maximum Consumption Quantity for the scenario.
Then the output will show the scenario's name, consumption quantity, intake of the chemical, and the ratio between the exposure and HBGV. In accordance with the opinion of most experts, EAST will provide a ratio in red ("unsafe") when the exposure exceeds the HBGV, assuming that the chemical is evaluated to be not genotoxic. The ratio will be presented in green ("safe") when exposure is less than the HBGV. For some genotoxic compounds, a slope factor can be used, whereas for other genotoxic chemicals a BMDL can be selected. In these cases the ratio will be presented in red if the Margin of Exposure is less than 10000.
For each scenario it will also show the Limit of Rejection.