Updating the ILV

During the development of the GIFT tool a few existing parts of the tools such as the selection of the chemical substance were updated. An important update refers to the test whether or not the intake exceeds the HBGV, BMDL, or slope factor. According to the procedure one must compare the intake with the Margin of Exposure (MoE). The MoE differs between using a HBGV or various BMDLs or a slope factor. To simplify this test it was decided to transform the HBGV and BMDL and slope factor into an "Intake Limit value" (ILV). This ILV includes the MoE, leading to a similar or lower limit. The test is now the same for all exposure limits; exceeding the ILV is similar to a "risk". The MoE is a relevant factor to set the ILV but there is no harmonized procedure on setting the value. Therefore the MoE for BMDLs can now be altered at wish in this Portal, and the ILV is updated accordingly.

In the figure it is shown that the BMDL01 for lead of 0.5 ug/kg/d with its default MoE of 1 corresponds with an ILV of 0.5 ug/kg/d. After clicking [Proceed] at this page, the ILV of 0.5 will be used. However, if the MoE is changed into 5 and after clicking [Update] the ILV is recalculated to be 0.1 ug/kg/d (BMDL: 0.5 ÷ MoE: 5) as shown in the figure. After clicking [Proceed] here the new ILV will be used for the risk characterization.